In univariate analysis, patient gender, baseline cardiovascular comorbidities (i.e., hypertension, atrial fibrillation, cardiovascular disease), the Rai and Binet stage, beta2-microglobulin (B2M), and lactate dehydrogenase (LDH) did not alter the PFS or OS (data not shown). This evidence concerns the gene B2M and atrial fibrillation.