Studies showed that biomarkers include PLD2 [117], FLNA (filamin A) [118], SMURF1 [119], LINGO1 [120], CACNA1H [121], NLRP6 [122], NLRC3 [123], CXCR2 [124] and C5AR1 [125] plays an important role in progression of hypertension. This evidence concerns the gene SMURF1 and hypertensive disorder.