Due to the interaction between ACE2 protein and SARS-CoV-2, viral propagation induced by the expression of RAAS-inhibitor-induced ACE2 has been regarded as an important mechanism associated with cardiovascular, hypertensive, and chronic kidney diseases, COVID-19 severity, and SARS-CoV-2 infection in different tissues [33,34]. The gene discussed is ACE2; the disease is chronic kidney disease.