Bromelain has previously been used in several in vitro and animal studies for a different range of medical practices including preventing edema formation, reducing blood fibrinogen levels, supporting fibrinolysis, plasmin activation, preventing the aggregation of blood platelets, reducing blood plasma-kinins levels, preventing the adhesion of blood vessel epithelial cells to platelets, inducing the secretion of proinflammatory factors in tumor cells, supporting the oxidative burst, and acting as an anti-inflammatory agent [22,23]. This evidence concerns the gene PLG and neoplasm.