In relation to laboratory findings, more than 95% of patients with SSc develop positive antinuclear antibodies (ANA), with ACA and anti-polymerase I being the most frequent, although up to seven specific ANA have been described; with anti-Scl70, anti-Th/To, and anti-U3RNP being those associated with a worse patient prognosis [17]. Here, BTG3 is linked to systemic sclerosis.