This adipose tissue is linked to metabolic syndrome, and it is associated with systemic low-grade inflammation because it produces different molecules, such as Plasminogen activator inhibitor-1 (PAI-1) and Monocyte chemoattractant protein 1 (MCP-1), that are correlated to increased risk of vascular inflammation and progression of atherosclerosis. This evidence concerns the gene SERPINE1 and atherosclerosis.