TNFSF10 and malignant colon neoplasm: Despite the fact that the majority of colon cancer cell lines are resistant to TRAIL-mediated apoptosis, TRAIL, in combination with flavonoids, leads to the synergistic induction of cell death [60,61] Further studies on the intracellular mechanism of TRAIL-mediated apoptosis may help overcome TRAIL resistance and develop approaches to colon cancer prevention based on flavonoids.