Santin significantly increased TRAIL-induced apoptosis to 42.68% ± 0.74%–73.78% ± 0.62% in SW480 cancer cells and to 39.90% ± 0.70%–93.67% ± 0.62% in SW620 cancer cells in comparison to TRAIL alone (Figure 2). This evidence concerns the gene TNFSF10 and cancer.