These proteins include β-amyloid (Aβ) of senile plaques and tau of neurofibrillary tangles (NFTs) in AD, α-synuclein (α-syn) of Lewy bodies (LBs) and Lewy neurites in PD, polyglutamine (PolyQ)-rich huntingtin inclusions in HD, TDP-43 aggregates in ALS, and TDP-43 aggregates and tau in FTD (Figure 3). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.