Resveratrol ameliorates DN progression by inhibiting nuclear factor-κB (NF-κB) activity and attenuating renal mesangial cell proliferation [64], lowering oxidative stress and downregulating receptor for advanced glycation end product (RAGE) expression [65], lowering AGE accumulation, oxidative damage, apoptosis, and NADPH oxidase 4 (NOX4) expression [66,67]. The gene discussed is NOX4; the disease is liver dysplastic nodule.