INS and liver dysplastic nodule: Another treatment strategy for DN is the administration of insulin and antidiabetic drugs, including sulfonylureas, biguanides, thiazolidinediones, insulin sensitizers, inhibitors of α-glycosidase, agonists of glucagon-like peptide, inhibitors of dipeptidyl peptidase-4, incretin-based drugs, and inhibitors of sodium-glucose cotransporter.