CASP3 and glioblastoma: Acteoside in 190 nm liposomal nanoparticles, able to penetrate the membrane in the process of macropinocytosis, showed significantly enhanced activity from IC50 of 85.0 and 44.0 μM to IC50 2.9 and 4.0 μM in glioblastoma cell lines T98G and U-138 MG, respectively, through an increase in apoptosis-associated proteins p35 and caspase-3 [54].