CXCR5 and neoplasm: This will allow important insights into anti-PD-1 treatment-related effects on the anti-tumor defense, functional regulation, and networks, such as the interplay of adaptive and innate CXCL13/CXCR5-associated components—from CXCL13-producing and attracting cells to various effectors that express a wide array of functions, ranging from cytotoxic and helper functions to humoral responses.