The functional activity of the receptors was reflected in the elevated synthesis of TNF-α by mononuclear phagocytes of the patients with severe BA in response to TLR2 and TLR4-specific ligands, but other pro-inflammatory cytokines, namely IL-6, IL-8, and IL-1b, did not display such dependency. Here, CXCL8 is linked to breast angiosarcoma.