CCN2 and liver dysplastic nodule: High glucose can induce the TGF-β type II receptor [69], excessive expression of connective tissue growth factor (CTGF) [70], increased production of circulating angiotensin II (Ang II) [71], and increased release and recruitment of monocyte chemoattractant protein-1 (MCP-1) [72] produced by MC pathological changes, such as DN glomerular hypertrophy, sclerosis, and ECM deposition.