ESR1 and breast carcinoma: Breast carcinoma with neuroendocrine features was divided into Luminal A (ER/PR positive, Her-2 negative with low Ki-67 index) disease, Luminal B (ER/PR positive, Her-2 negative with high Ki-67 index, or ER/PR positive, Her-2 positive) disease, Her-2 positive (ER and PR negative, Her-2 positive) disease, and Triple-negative (ER, PR, and Her-2 negative) disease according to molecular subtyping.