Thus, EBV+ DLBCL displays a tolerogenic TME with an increased expression of PDL1, PDL2, LAG3, and TIM3 immune checkpoints [82,117,118]; raised levels of immunosuppressive cytokines (e.g., IL10) [118]; and higher pro-tumoral loads of CD163/CD68 “M2” macrophages [117]. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.