In addition, elevated P300 can bind to CREB to drive the gene expression of Pck1 and G6pc. These data reveal the significance of changes in the composition of gut microbiota and the increase in intestinal permeability and LPS leakage, and their initiated low-grade inflammation in the development of hyperglycemia in T2DM and obesity. Here, CREB1 is linked to Hyperglycemia.