GBA2 and amyotrophic lateral sclerosis: Conduritol B epoxide, a GBA2 inhibitor, has been found to increase the level of glucosylceramide, significantly attenuating the deregulation of genes involved in ALS pathogenesis, and they also preserve the functionality of the neuromuscular junction, preventing motor neuron death in a SOD1G86R mice model of ALS [112].