An increase in GCS activity (i.e., intensification of the formation of glucosylceramide from ceramide) has been identified as a negative regulator of ceramide-induced apoptosis [111], which once again indicates a potential protective role of glucosylceramide in ALS, possibly through the weakening of the toxic effect of ceramide. The gene discussed is UGCG; the disease is amyotrophic lateral sclerosis.