However, over the past 20 years, mouse models of ALS expressing SOD1, mainly the SOD1G93A variant and further the SOD1G37R, SOD1G85R, and SOD1G86R ones, have been used to characterize the pathology of ALS, as well as to study the specific benefits of potential treatments [30,31]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.