SOD1 and amyotrophic lateral sclerosis: Currently, one of the most studied nitroalkenes is nitro-oleic acid, and its anti-inflammatory properties have been shown to be based on the ability to penetrate through the BBB and include a reduction in prostaglandin and hydroxyeicosatrienoic acid levels in the brain, as well as a reduction in astrogliosis in the spinal cord of ALS animal models (SOD1 mice) [72,73].