In the ADVANE trial of 3098 participants with type 2 DM, one standard deviation increase in interleukin-6 (IL-6) (hazard ratio: 1.48, 95% confidence interval: 1.27 to 1.72) or high sensitivity CRP (hazard ratio: 1.32, 95% confidence interval: 1.12 to 1.55) was associated with a higher risk of HF incidence or progression [60]. This evidence concerns the gene CRP and hydrops fetalis.