In agreement with these findings, the number of neutrophils in the arterial intima has been also found to positively correlate with the signs of plaque vulnerability in humans and mice [7] as well as neutrophil myeloperoxidase (MPO) inhibition to reduce the necrotic core in the experimental atherosclerosis of the aortic roots in mice [8]. The gene discussed is MPO; the disease is atherosclerosis.