Regarding diabetic cardiomyopathy (DbCM), KLF-5 has been linked to oxidative stress via the upregulation of NADPH oxidase 4 (NOX4) by directly binding to NADPH oxidase 4 promoter, inducing NOX4 expression, and leading to cardiomyocyte superoxide accumulation, mitochondrial abundance decrement, and a change in the cardiac lipidome profile toward a ceramide-rich environment; therefore, contributing to DbCM physiopathology [15]. Here, NOX4 is linked to diabetic cardiomyopathy.