KLF4 and Marfan syndrome: Recently, KLF-4 has been linked to Marfan syndrome, a commonly inherited connective tissue disorder caused by mutations in the Fibrillin-1 gene, characterized by physical features such as increased height, scoliosis, arachnodactyly, lens dislocation, and cardiovascular disorders, including mitral valve prolapse and aortic aneurism, which can trigger aortic dissection [105,106].