Numerous studies have used a high-fat diet (HFD) to induce MAFLD and NASH (without progression to fibrosis) in mice, in order to identify the axis between TH17/regulatory T cells (Treg) and IL-17, considered to be an important part of the inflammatory factors underlying the transition from hepatic steatosis to NASH [34,63,64,65,66]. This evidence concerns the gene IL17A and Hepatic steatosis.