Vicenin-2 (1) also caused specific morphological changes in prostate carcinoma PC-3 and LNCaP cells, namely, chromatin clumping, as well as increased caspase-3 cleavage [53], which further corroborated the in vitro anticancer effects in mice bearing PC3 cells, vicenin-2 (1) being shown to induce potent regression of tumours and with PARP-cleavage being also recorded, thus supporting the pro-apoptotic effects of the apigenin derivative [53]. This evidence concerns the gene CASP3 and prostate carcinoma.