Similarly to what we have found with A. africanus stem bark extract in AGS cells (Figure 3), activation of apoptosis by vicenin-2 (1) in the solid tumour cells NCI-H23 (non-small cell lung cancer) and HT-29 (human colon cancer) derives from the activation of caspase-3 [32,52], increased expression of cytochrome c being also reported to occur in the latter ones [52]. Here, CASP3 is linked to malignant colon neoplasm.