TNF and obstructive sleep apnea syndrome: Over the years, several inflammatory mediators have been corelated with the pathogenesis of OSA; however, some are more extensively researched and notably reported, including CRP, IL-6, IL-8, IL-33 and its receptor ST2, Pentraxin-3 (PTX-3), procalcitonin (ProCT), and TNF-a [57,58].