HMOX1 and rheumatoid arthritis: Resveratrol is an important compound of stilbenes that is present in the outer layer of the skin of grapes [93] and that increases the expression of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 in H2O2 treated (RA-FLS) RA fibroblast-like synoviocyte cells.