NFE2L2 and colorectal cancer: The authors in [70] showed that hydroxytyrosol induces apoptosis in the LS180 colorectal cancer cell line by upregulation of pro-apoptotic genes such as BAX, CASP3, and P53, and also increases the BAX:BCL2 ratio and decreases nuclear factor erythroid 2-related factor 2 (NFE2L2) expression.