In the diabetic kidney, HGF targets glomerular cells and reduces both glomerular and tubulointerstitial fibrosis [23,61].Another possible mechanism involves the activation of autophagy-lysosome pathwaysin podocytes [55,62,63].Unexpectedly, we found elevated excretion of HGF in patients with T2D, especially in those with albuminuric CKD. The gene discussed is HGF; the disease is type 2 diabetes mellitus.