SERPINE1 and Rare hereditary thrombophilia: We also performed complete thrombophilia tests, including Factor V G1691A (Leiden), Factor V H1299R (R2), MTHFR C677T, MTHFR A1298C, Factor XIII V34L, PAI-1 4G/4G, Factor II G20210A and Endothelial Protein C Receptor (EPCR) A1/A2 coupled with serology for: Ac anti-cardiolipin IgG and IgM, Ac anti-Beta2 glycoprotein 1, Ac-anti phospholipid IgG and IgM, lupus anticoagulant, homocysteine, and protein C and S activity.