In severe COVID-19, some altered parameters are common to septic states, such as C-reactive protein (CRP), procalcitonin (PCT), ferritin, D-dimers and fibrinogen, while others indicate, more specifically, a hyper-activation of the immune system and are often present in systemic autoimmune diseases, such as pro-inflammatory cytokine levels, e.g., interleukin-6 (IL-6) and interleukin-10 (IL-10), and reduction of both total lymphocytes and specific lymphocyte subsets [4,5,6]. The gene discussed is CRP; the disease is COVID-19.