This study has shown a significant influence of H. polygyrus infection on a variety of growth factors related mainly to angiogenesis in the intestinal mucosa of C57BL/6 colitic mice and in the cerebral spinal fluid of C57BL/6 mice with experimental autoimmune encephalomyelitis:VEGF, EGF, amphiregulin (AREG), FGF-2, FGF-7, GM-CSF, HGF, IGFBP-3, PDGF-AA, PDGF-BB. The gene discussed is IGFBP3; the disease is experimental autoimmune encephalomyelitis.