PIK3CA and thymic carcinoma: Unsurprisingly, thymic carcinomas harbor the highest molecular complexity among TETs, showing common alterations in CDKN2A, TP53, and ZNF429, and less frequently KIT, PTEN/PI3K/mTOR, ATM, ALK, ERBB2, and CYLD1 genetic abnormalities [5,6,7].