TP53 and thymic carcinoma: Furthermore, BCL2 copy gain, CDKN2A copy loss (due to chromosome 16 CNV), and mutations in TP53, ZNF429, and epigenetic regulatory genes (i.e., BAP1, ASXL1, TET2, DNMT3A, etc.)are the most frequent genetic abnormalities in thymic carcinoma [6,87,88].