Specifically, the four groups are divided as follows: the GTF2I mutated group, with the most favorable histology, lower Masaoka stage, and rare association with MG; the GTF2I wild-type group with a T-cell signaling profile (TS group); the GTF2I wild-type group with low CNVs (chromosomally stable group, CS); and the GTF2I wild-type group with chromosomal instability (chromosomal instability group, CIN), with the most aggressive histology, higher Masaoka stage, and more frequent association with MG. This evidence concerns the gene GTF2I and cervical squamous intraepithelial neoplasia.