Specifically, the four groups are divided as follows: the GTF2I mutated group, with the most favorable histology, lower Masaoka stage, and rare association with MG; the GTF2I wild-type group with a T-cell signaling profile (TS group); the GTF2I wild-type group with low CNVs (chromosomally stable group, CS); and the GTF2I wild-type group with chromosomal instability (chromosomal instability group, CIN), with the most aggressive histology, higher Masaoka stage, and more frequent association with MG. Here, GTF2I is linked to myasthenia gravis.