In a T-cell-derived T-ALL lymphocytic leukemia cell line, which lacked functioning p53 and p16, RSV caused apoptosis and an arrest in the S-phase, in a way that was Fas-independent as evidenced by the lack of an apoptotic change in the presence of Fas or FasL antagonist antibodies [116]. The gene discussed is FAS; the disease is acute lymphoblastic leukemia.