TGFB1 and Familial prostate cancer: Since inflammation is one of the factors involved in the tumorigenesis process, and TLR-4 represents the most studied pathway, several authors have shown that TLR-4 activation leads to IL-8 and IL-6 increased expression in breast cancer, also associated with VEGF and TGF-β increased expression in prostate cancer, in which their overexpression is also very often associated with poor prognosis [68].