Circulating extracellular vesicles from patients with advanced hepatocellular carcinoma have an abundance of PIGR, which can promote cancer aggressiveness together with stemness of Huh7 cells through activating the PDK1/Akt/GSK3β/β-catenin signaling axis, and PIGR is over-accumulated in hepatocellular cancer tissues predicting a decreased disease-free survival rate [57,58]. This evidence concerns the gene GSK3B and hepatocellular carcinoma.