POLE and cancer: The World Health Organization (WHO) classification from 2020 and ESGO/ESTRO/ESP guidelines also take into consideration molecular developments in the subclassification of endometrial carcinoma [6,7], which subdivide them into four overarching categories: no specific molecular profile (NSMP), mismatch repair deficient tumors (MMR-d) and ultra-mutated cancers with polymerase epsilon (POLE) mutations (POLE-mut).