NPPB and Sepsis: A systematic review and meta-analysis of 36 studies and 3508 patients found that BNP and NT-proBNP are frequently elevated in patients with sepsis, are prognostic in this population, and that the optimal cutoff points for BNP and NT-proBNP were calculated at 622 pg/mL and 4000 pg/mL for short-term prediction of mortality in patients with sepsis and septic shock [41].