Although we have already hypothesized a possible role of IgG3 in the pathogenesis of primary biliary cirrhosis (PBC) [9] or mixed cryoglobulinemia (MC) [28], strengthening the hypothesis of a pathogenic role of IgG3 in liver-related autoimmunity, to date there are no studies in the literature about the possible role of IgG3 in initiation or progression of ILD in SSc patients. Here, IGHG3 is linked to primary biliary cholangitis.