TNF and Abnormal renal physiology: Moreover, from the present findings, it was found that creatine or LC exhibits potent anti-oxidant and anti-inflammatory activity via regulation of several varieties of free radicals and cytokines by improving the effect of anti-oxidant enzymes such as CAT, SOD, GSH, etc., and inflammatory cytokines such as TNF, ILs, NF-Kb, etc. However, several myths are based on the recommendation of protein supplements to patients associated with CKD or renal dysfunction, as the protein supplements increase the protein and creatinine levels more than normal, effecting the glomerular filtration rate [69].