ANO1, which is found on locus 11q13, is amplified in multiple tumors, particularly in gastrointestinal stromal tumors (GIST) and head and neck squamous cell carcinoma (HNSCC), in addition to numerous others, such as lung adenocarcinoma, chondroblastoma, esophageal squamous cell carcinoma, salivary gland tumors, oral squamous cell carcinoma, leiomyosarcoma of the uterus, glioma, breast, colorectal and prostate cancer [39,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. This evidence concerns the gene ANO1 and oral cavity squamous cell carcinoma.