ANO1, which is found on locus 11q13, is amplified in multiple tumors, particularly in gastrointestinal stromal tumors (GIST) and head and neck squamous cell carcinoma (HNSCC), in addition to numerous others, such as lung adenocarcinoma, chondroblastoma, esophageal squamous cell carcinoma, salivary gland tumors, oral squamous cell carcinoma, leiomyosarcoma of the uterus, glioma, breast, colorectal and prostate cancer [39,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. The gene discussed is ANO1; the disease is head and neck squamous cell carcinoma.