The relations between macrophage ABCA-1 receptor lipid levels and atherosclerosis were investigated in an experimental study on mice, and it was reported that ABCA-1 deficit increased foam cell accumulation and inflammation; in other words, it had a dual effect on both lipid profile and inflammation suggesting that ABCA1 deficiency is closely related to HDL-C metabolism and inflammation processes [9]. Here, ABCA1 is linked to atherosclerosis.