Resveratrol could inhibit activation of microglia and inflammation, decrease infarct volume, and improve the neurological functional outcome in the acute phase of stroke, trigger the translocation of Smo to primary cilia from cytoplasm, and upregulate the expression levels of Shh, Ptc-1, Smo, and Gli-1 after OGD/R injury of microglia in vitro. Here, SHH is linked to stroke disorder.