Recent literatures reported that resveratrol could inhibit oxidation and apoptosis in neurodegenerative diseases through the Nrf2/HO-1, SIRT1, RAX/P-PKR, and JAK2/STAT3/PI3K/AKT/mTOR signaling pathways [43,44,45,46]. This evidence concerns the gene SIRT1 and neurodegenerative disease.