The activity of the mitochondrial respiratory chain complex I in lung tissue decreased significantly in CLP group (p < 0.05, CLP vs. Sham), but there was no significant change in the activity of the mitochondrial respiratory chain complex II in the CLP mouse model compared with the control group (p > 0.05, CLP vs. Sham), indicating that sepsis may damage the activity of mitochondrial respiratory chain complex I in lung tissue, but had no significant effect on the activity of complex II. Here, NDUFV1 is linked to Sepsis.