HMGB1 and Sepsis: We detected it and found that the expression of HMGB1 in lungs and serum of mice with moderate and severe sepsis increased significantly (p < 0.05, Moderate CLP vs. Sham; p < 0.05, Severe CLP vs. Sham), while 67% of the hydrogen inhalation treatment can significantly reduce the content of HMGB1 of septic mice (p < 0.05, Moderate CLP + 67% H2 vs. Moderate CLP; p < 0.05, Severe CLP + 67% H2 vs. Severe CLP) (Figure 3D).