The association between PD-L1 expression and clinicopathological features was analyzed, age (≥65 vs. <65 years), gender (male vs. female), localization (acral, upper body, cervico-cranial, limb), Clark level of invasion (I, II, III, IV, V), Breslow tumor thickness (<1 mm; 1–2 mm; 2–4 mm; >4 mm), lymphovascular invasion (present, absent), perineural invasion (present, absent) (Table 1). This evidence concerns the gene CD274 and neoplasm.