Melanomas negative for PD-L1 show a significant degree of staining (2+) by CD4 and CD8 infiltrating lymphocytes (CD8+TILs: 58.53%; MTCs: 75.76%, CD4+TILs: 70.83%; MTCs: 87.88%, p < 0.05). The gene discussed is CD8A; the disease is melanoma.