The incidence of PDL-1 positive expressions for patients with acral and cervico-cranial localization of melanoma was notably lower than for patients with upper body and limbs localizations of melanoma (TILs-A:5.41%; CC:8.11% vs. UB:51.35%; L:35.14%, p < 0.05; MTCs-A:7.10%; CC:17.86% vs. UB:53.62%; L:21.43%, p ≥ 0.05). The gene discussed is CD274; the disease is melanoma.