PD-L1 (+) patterns associated with moderate to severe CD8+ and CD4+ lymphocytes intensities (CD8+TILs: 69.57%; MTCs: 75.00%; CD4+TILs: 97.30%; MTCs: 85.71%) compared to mild (CD8+TILs: 2.79%; MTCs: 7.14%, CD4+TILs: 0.00%; MTCs: 3.57%, p < 0.05) were observed in the majority of morphological types of melanomas (Table 2) (Figure 1, Figure 2, Figure 3, Figure 4 and Figure 5). This evidence concerns the gene CD4 and melanoma.