Additionally, through the use of a deconvolution method and DEG analysis, this study also identified a gene signature consisting of ACP7, EPPK1, PCDHA8, RHOD, DRC1, ZIC3, and PRLR that are associated with poor prognosis in patients with GBM who were treated with TMZ. The gene discussed is EPPK1; the disease is glioblastoma.