CARD9 and infection: This may happen due to patients’ poor compliance to treatment owing to the regimen’s long duration, the emerging problem of infections by resistant strains or otherwise due to specific patient characteristics (differences in the composition of keratin among individuals that make dermatophytes host specific [73], defects of phagocytes [3], CARD9 deficiency [74] and individuals with a defective skew to Th2 immunity that may exhibit a predisposition to chronic dermatophytic infections [73]).