One study found that patients with coccidioidomycosis had higher serum IL-6, IL-18, IL-12, and IL-10 than controls [63], while another reported no difference in constitutive TNF-α, IL-1β, or IL-6 concentrations in supernatant from patients with active coccidioidomycosis and healthy controls [64]. The gene discussed is IL18; the disease is coccidioidomycosis.