TNF and coccidioidomycosis: Dogs with coccidioidomycosis produced higher coccidioidal stimulated supernatant concentrations of TNF-α (p = 0.003), IL-6 (p = 0.04), IFN-γ (p = 0.03), MCP-1 (p = 0.02), IL-10 (p = 0.02), and lower IL-8 (p = 0.003) than controls (Table 4).