For necroptosis, elevated levels of receptor-interacting protein serine-threonine kinases-1 (RIPK1), phosphorylated RIPK3, mixed lineage kinase domain-like protein (MLKL), and phosphorylated MLKL were observed in gingival tissues collected from patients with untreated chronic periodontitis [15]. Here, MLKL is linked to chronic periodontitis.