In the atherosclerosis/lupus-prone mouse model, researchers demonstrated that the BAFF-BAFFR (B-cell–activating factor receptor) signal in B cells and the BAFF-TACI signal in macrophages play a double-edged role in both atheroprotective and proatherogenic effects [24]. This evidence concerns the gene TNFRSF13C and systemic lupus erythematosus.