In this study, we used two-sample MR univariate and multivariable analyses to examine potential causal associations between three types of COVID-19 (very severe respiratory syndrome, hospitalization, and susceptibility) and eight CNS-regulated hormones [IGF-1, estrogen, testosterone, DHEA, TSH, thyrotropin-releasing hormone (TRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH)]. The gene discussed is TRH; the disease is COVID-19.