Voelkl et al. [6] have reported that serum zinc levels were negatively correlated with a propensity for serum calcification in CKD patients and that zinc sulfate supplementation suppressed vascular calcification in CKD model mice via the increased aortic expression of TNFAIP3, which is a suppressor of the NF-κB transcription factor pathway. The gene discussed is TNFAIP3; the disease is chronic kidney disease.