Of note, the InterTAK Registry investigators have reported a higher rate of Takotsubo syndrome (TTS) in cancer patients compared with the general population as a consequence of cancer treatments toxicity (e.g., 5-fluorouracil (5-FU), ICI, vascular endothelial growth factor inhibitors (VEGFi) and tyrosine kinase inhibitors (TKIs)) along with increased emotional stress and elevated sympathetic tone [8]. This evidence concerns the gene VEGFA and cancer.