As our study was a small cohort retrospective study and was not adjusted for other factors (e.g., starting dose of nal-IRI), further investigation is needed to determine the effect of UGT1A1*1/*28 or *1/*6 on neutropenia related to nal-IRI+5-FU/LV. The gene discussed is UGT1A1; the disease is Decreased total neutrophil count.