In this case, the best course of action may be to inhibit MCT1-4 transporters for lactate efflux and BHB influx; the lactic acid accumulation would then block LDH, impairing the supply of NAD+ and tumor glycolysis, while the decrease in BHB influx would starve the tumor cell, impairing the supply of mitochondrial acetyl-CoA. This evidence concerns the gene SLC16A1 and neoplasm.